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生物来源
mouse
重组
expressed in E. coli
检测方案
≥95% (HPLC)
≥95% (SDS-PAGE)
形式
lyophilized
分子量
~16.3 kDa
包装
pkg of 50 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Fgf2(14173)
一般描述
FGF-2 (fibroblast growth factor 2) is a basic heparin binding growth factor. It is ubiquitously expressed and belongs to the FGF family. It is also referred to as BFGF (basic fibroblast growth factor). The recombinant mouse FGF-2 is a single, non-glycosylated chain containing 145 amino acids and having a molecular weight of 16.3kDa.
生化/生理作用
FGF-2 (fibroblast growth factor 2, also referred to as BFGF (basic fibroblast growth factor)) stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. It is present in the preimplantation embryos and is important for proper development. It is also responsible for angiogenesis. FGF-2 plays a crucial role in adipogenesis and development of adipose tissues. It is associated with tumor growth and metastasis.
外形
Sterile filtered and Lyophilized without additives.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile water to 100 μg/mL.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Biphasic effects of FGF2 on adipogenesis.
Kim S
PLoS ONE, 10, e0120073-e0120073 (2015)
Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway.
Yang J
Cell Cycle, 14, 3318-3330 (2015)
Blocking FGF2 with a new specific monoclonal antibody impairs angiogenesis and experimental metastatic melanoma, suggesting a potential role in adjuvant settings.
de Aguiar RB
Cancer Letters, 371, 151-160 (2016)
Interleukin-1? induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes.
Chien SY
Clinical Science, 130, 667-681 (2016)
Yongyi Wang et al.
PloS one, 7(7), e40691-e40691 (2012-08-01)
In fertile women, the endometrium undergoes regular cycles of tissue build-up and regression. It is likely that uterine stem cells are involved in this remarkable turn over. The main goal of our current investigations was to identify slow-cycling (quiescent) endometrial
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