生物来源
mouse
重组
expressed in E. coli
检测方案
≥98% (HPLC)
≥98% (SDS-PAGE)
形式
lyophilized
效能
5x10^7 units/mg ED50
分子量
21.7 kDa
包装
pkg of 10 μg
杂质
endotoxin, tested
颜色
white to off-white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... IL6(16193)
一般描述
鼠IL-6对人细胞无活性，而人和鼠IL-6对鼠细胞的活性相同。 重组鼠IL-6是含有188个氨基酸残基的21.7 kDa蛋白质。
应用
来自小鼠的IL-6已用于研究IL-6介导的对小鼠前脂肪细胞分化的抑制作用。
生化/生理作用
IL-6是一种多效细胞因子，它能够调节免疫和炎症反应，从而在宿主防御中发挥重要作用。IL-6由T细胞、单核细胞、成纤维细胞、内皮细胞和角质形成细胞产生，具有多种生物学功能。它能刺激B细胞分化和抗体产生，与IL-3协同作用于巨核细胞发育和血小板生成，诱导肝急性期蛋白的表达，并调节骨代谢。IL-6通过IL-6受体系统发出信号，该系统由IL-6R和gp130两条链组成。
外形
从0.1％TFA中冻干获得
重悬
打开样品瓶之前需离心。 在水中重悬至浓度为 0.1-1.0mg/ml。不可涡旋。 该溶液可在2-8°C下储存长达1周。 为了延长储存时间，建议可在含有载体蛋白（如0.1％ BSA）的缓冲液中进行进一步的稀释，并分装冻存在-20℃至-80℃下。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The biology of interleukin-6.
Kishimoto T
Blood, 74, 1-10 (1989)
Lichun Chen et al.
Foods (Basel, Switzerland), 11(20) (2023-07-11)
Dietary intervention is becoming more popular as a way to improve lipid metabolism and reduce the prevalence of diet-related chronic disorders. We evaluated the effects of several dietary oils on body weight, fat mass, liver weight, and tumor necrosis factor
Polyinosinic-polycytidylic acid inhibits the differentiation of mouse preadipocytes through pattern recognition receptor-mediated secretion of tumor necrosis factor-a.
Yu L
Immunology and Cell Biology, 94, 875-885 (2016)
Lili Yu et al.
Immunology and cell biology, 94(9), 875-885 (2016-10-19)
Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors
Suzanne Speck et al.
PloS one, 9(7), e102390-e102390 (2014-07-30)
While the role of Transforming Growth Factor β (TGF-β) as an intrinsic pathway has been well established in driving de novo differentiation of Th17 cells, no study has directly assessed the capacity of TGF-β signaling initiated within dendritic cells (DCs)
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