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主要文件

安全信息

SRP3325

Sigma-Aldrich

Uterglobin Peptide

≥98% (HPLC), human recombinant, expressed in E. coli

别名:

Clara cell phospholipid-binding protein, Secretoglobin family 1A member 1, Urinary protein 1

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About This Item

UNSPSC代码:
12352202
NACRES:
NA.32

产品名称

UTERGLOBULIN human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

生物来源

human

重组

expressed in E. coli

方案

≥98% (HPLC)
≥98% (SDS-PAGE)

表单

lyophilized

分子量

8.0 kDa

包装

pkg of 50 μg

杂质

endotoxin, tested

UniProt登记号

运输

wet ice

储存温度

−20°C

基因信息

human ... SCGB1A1(7356)

一般描述

Uteroglobin, also known as clara cell phospholipid-binding protein or CC10, is a member of the secretoglobin superfamily. It is secreted from nonciliated cells in the epithelial lining of bronchioles, also referred as Clara cells. Uteroglobin is encoded by the gene mapped to human chromosome 11q12.2 – 13.1. Recombinant Human Uteroglobin is an 8.0kDa homodimeric protein consisting of 142 amino acid residues.

生化/生理作用

Uteroglobin functions as an immunomodulatory and anti-inflammatory protein. Uteroglobin might play a vital role in regulation of airway inflammation. Elevated level of uteroglobin has been observed in fallopian tubes of tubal ectopic pregnant women and in female patients with pelvic inflammatory disease. Uteroglobin level is reduced in serum of asthmatic patients with a long duration of the disease. Uteroglobin stimulates the growth of preimplantation blastocysts and it functions as a carrier and/or scavenger of progesterone, decreasing its toxicity to the early developing embryo. Uteroglobin has the capacity to prevent both chemotaxis and phagocytosis of monocytes and neutrophils.

外形

Lyophilized from 1 x PBS

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma.
Shijubo N
Lung, 177(1), 45-52 (1999)
Current knowledge of the aetiology of human tubal ectopic pregnancy.
Shaw JL
Human Reproduction Update, 16(4), 432-444 (2010)
Uteroglobin: a novel cytokine?
Mukherjee AB
Cellular and Molecular Life Sciences, 55(5), 771-787 (1999)
Anil B Mukherjee et al.
Endocrine reviews, 28(7), 707-725 (2007-10-06)
Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology. However, the physiological function(s) of UG still remains elusive. Isolated from the uterus of rabbits

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