推荐产品
产品名称
UTERGLOBULIN human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
生物来源
human
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
分子量
8.0 kDa
包装
pkg of 50 μg
杂质
endotoxin, tested
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... SCGB1A1(7356)
一般描述
Uteroglobin, also known as clara cell phospholipid-binding protein or CC10, is a member of the secretoglobin superfamily. It is secreted from nonciliated cells in the epithelial lining of bronchioles, also referred as Clara cells. Uteroglobin is encoded by the gene mapped to human chromosome 11q12.2 – 13.1. Recombinant Human Uteroglobin is an 8.0kDa homodimeric protein consisting of 142 amino acid residues.
生化/生理作用
Uteroglobin functions as an immunomodulatory and anti-inflammatory protein. Uteroglobin might play a vital role in regulation of airway inflammation. Elevated level of uteroglobin has been observed in fallopian tubes of tubal ectopic pregnant women and in female patients with pelvic inflammatory disease. Uteroglobin level is reduced in serum of asthmatic patients with a long duration of the disease. Uteroglobin stimulates the growth of preimplantation blastocysts and it functions as a carrier and/or scavenger of progesterone, decreasing its toxicity to the early developing embryo. Uteroglobin has the capacity to prevent both chemotaxis and phagocytosis of monocytes and neutrophils.
外形
Lyophilized from 1 x PBS
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma.
Lung, 177(1), 45-52 (1999)
Current knowledge of the aetiology of human tubal ectopic pregnancy.
Human Reproduction Update, 16(4), 432-444 (2010)
Uteroglobin: a novel cytokine?
Cellular and Molecular Life Sciences, 55(5), 771-787 (1999)
Endocrine reviews, 28(7), 707-725 (2007-10-06)
Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology. However, the physiological function(s) of UG still remains elusive. Isolated from the uterus of rabbits
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