产品名称
G-CSF 人, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
10.0-25.0 ng/mL
mol wt
18.7 kDa
packaging
pkg of 10 μg
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CSF3(1440)
Biochem/physiol Actions
粒细胞集落刺激因子 (Granulocyte colony stimulating factor,G-CSF) 或集落刺激因子 3 (colony stimulating factor 3,CSF-3) 是一种造血生长因子，可刺激定向祖细胞向中性粒细胞发展，增强成熟终末细胞的功能活性。控制粒细胞的产生、分化和功能。G-CSF 正应用于临床，以利于骨髓移植后的造血恢复。该蛋白已被证明在动物模型的骨修复中发挥作用，并在临床上被批准用于中性粒细胞减少症的治疗。
General description
粒细胞集落刺激因子 (G-CSF) 或集落刺激因子 3 (CSF-3) 是在多种细胞（包括巨噬细胞、成纤维细胞、内皮细胞和骨髓基质）的特异性刺激下产生的。人和鼠 G-CSF 具有跨物种反应性。编码 G-CSF 的基因定位于人类 17 号染色体。重组人 G-CSF 是由 174 个氨基酸残基组成的 18.7 kDa 蛋白。
Physical form
从 5 mM 柠檬酸钠 (pH 4.0) 冻干。
Preparation Note
打开前离心小瓶。用水复溶至 0.1-1.0 mg/mL 浓度。切勿涡旋。该溶液可在 2-8°C 条件下至多储存 1 周。为了延长储存时间，建议在含有载体蛋白（例如 0.1%BSA）的缓冲液中进一步稀释，并在-20°C 至-80°C 下储存。
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Effect of Granulocyte-Colony Stimulating Factor on Endothelial Cells and Osteoblasts.
Liu XL
BioMed Research International, 8485721-8485721 (2016)
Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma.
Swift A
British Journal of Cancer, 71(5), 995-998 (1995)
H S Lu et al.
Archives of biochemistry and biophysics, 268(1), 81-92 (1989-01-01)
Molecular characteristics and secondary structures of recombinant methionyl human granulocyte colony stimulating factor produced by genetically engineered Escherichia coli are described. Limited radiolabeling of the protein with tritiated iodoacetate and determination of the labeled residue revealed that this recombinant protein
Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Kim JS
Oncology Reports, 34(1), 147-154 (2015)
Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.
Meshkibaf S
Cytokine, 78, 69-78 (2016)
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