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生物来源
human
重组
expressed in E. coli
检测方案
≥98% (HPLC)
≥98% (SDS-PAGE)
形式
lyophilized
效能
10.0-25.0 ng/mL
分子量
18.7 kDa
包装
pkg of 10 μg
杂质
<0.1 EU/μg endotoxin, tested
颜色
white to off-white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CSF3(1440)
一般描述
粒细胞集落刺激因子 (G-CSF) 或集落刺激因子 3 (CSF-3) 是在多种细胞（包括巨噬细胞、成纤维细胞、内皮细胞和骨髓基质）的特异性刺激下产生的。人和鼠 G-CSF 具有跨物种反应性。编码 G-CSF 的基因定位于人类 17 号染色体。重组人 G-CSF 是由 174 个氨基酸残基组成的 18.7 kDa 蛋白。
生化/生理作用
粒细胞集落刺激因子 (Granulocyte colony stimulating factor,G-CSF) 或集落刺激因子 3 (colony stimulating factor 3,CSF-3) 是一种造血生长因子，可刺激定向祖细胞向中性粒细胞发展，增强成熟终末细胞的功能活性。控制粒细胞的产生、分化和功能。G-CSF 正应用于临床，以利于骨髓移植后的造血恢复。该蛋白已被证明在动物模型的骨修复中发挥作用，并在临床上被批准用于中性粒细胞减少症的治疗。
外形
从 5 mM 柠檬酸钠 (pH 4.0) 冻干。
重悬
打开前离心小瓶。用水复溶至 0.1-1.0 mg/mL 浓度。切勿涡旋。该溶液可在 2-8°C 条件下至多储存 1 周。为了延长储存时间，建议在含有载体蛋白（例如 0.1%BSA）的缓冲液中进一步稀释，并在-20°C 至-80°C 下储存。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
H S Lu et al.
Archives of biochemistry and biophysics, 268(1), 81-92 (1989-01-01)
Molecular characteristics and secondary structures of recombinant methionyl human granulocyte colony stimulating factor produced by genetically engineered Escherichia coli are described. Limited radiolabeling of the protein with tritiated iodoacetate and determination of the labeled residue revealed that this recombinant protein
Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Kim JS
Oncology Reports, 34(1), 147-154 (2015)
Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma.
Swift A
British Journal of Cancer, 71(5), 995-998 (1995)
Akiko Sugiyama et al.
Chronobiology international, 32(7), 934-941 (2015-07-15)
Circulating hematopoietic stem cells exhibit robust circadian fluctuations, which influence the mobilized cell yield, even during enforced stem cell mobilization. However, alterations in the expression of circadian clock genes during granulocyte colony-stimulating factor (G-CSF)-induced peripheral blood stem cell (PBSC) mobilization
Jessy Arbez et al.
Cytotherapy, 17(7), 948-955 (2015-03-31)
This study aimed to characterize the immune effectors contained in the grafts from donor mice mobilized by granulocyte colony-stimulating factor (G-CSF) and plerixafor and to evaluate their impact on the development of acute graft-versus-host-disease (aGVHD). Mobilization was done with G-CSF
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