SRP3184
VEGF-C human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
别名:
VRP, Vascular Endothelial Growth Factor-C, flt4 ligand
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (HPLC), ≥95% (SDS-PAGE)
form
lyophilized
mol wt
30.0-33.0 kDa
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VEGFC(7424)
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General description
Vascular endothelial growth factor-C (VEGF-C) is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. It forms cell surface-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. Recombinant human VEGF-C is a 13.5kDa disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 30.0-33.0 kDa band by SDS-PAGE analysis under non-reducing condition.
Biochem/physiol Actions
Vascular endothelial growth factor-C (VEGF-C) is a potent angiogenic factor. It promotes endothelial cell growth, lymphangiogesis and can also affect vascular permeability. VEGF-C can bind and activate both vascular endothelial growth factor receptors-2 and -3 (also known as flk1 and flt4 respectively). During embryogenesis, the protein may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
Other Notes
AHYNTEILKS IDNEWRKTQC MPREVCIDVG KEFGVATNTF FKPPCVSVYR CGGCCNSEGL QCMNTSTSYL SKTLFEITVP LSQGPKPVTI SFANHTSCRC MSKLDVYRQV HSIIRR
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Ellen C Breen
Journal of cellular biochemistry, 102(6), 1358-1367 (2007-11-06)
Vascular endothelial growth factor A (VEGF-A) belongs to a family of heparin binding growth factors that include VEGF-B, VEGF-C, VEGF-D, and placental-like growth factor (PLGF). First discovered for its ability to regulate vascular endothelial cell permeability, VEGF is a well-known
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis.
Nagy JA
The Journal of Experimental Medicine, 196(11), 1497-1506 (2002)
Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer.
Neagoe PE
The Journal of Biological Chemistry, 280(11), 9904-9912 (2005)
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease.
Holmes DI and Zachary I
Genome Biology, 6(2), 209-209 (2005)
Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma.
Skobe M
The Journal of Investigative Dermatology, 113(6), 1047-1053 (1999)
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