SRP3128
NT-3 人
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
别名:
HGNF, NGF-2, 神经生长因子-2, 神经营养因子, 神经营养因子-3
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
potency
≤20 ng/mL ED50/EC50
mol wt
13.6 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NTF3(4908)
正在寻找类似产品? 访问 产品对比指南
General description
NT-3（神经营养蛋白3）是与β-NGF（神经生长因子）、BDNF（脑源性神经营养因子）和NT-4结构相关的神经营养因子。这些蛋白属于生长因子的半胱氨酸结家族，其具有稳定的二聚体结构。NT-3由中枢神经系统的神经元表达，并可通过trk受体发出信号。 重组人NT-3是一个非共价连接的同源二聚体，具有两个13.6kDa多肽单体（总共240个氨基酸残基）。人、小鼠和大鼠的NT-3的氨基酸序列是相同的。
Biochem/physiol Actions
NT-3（神经营养因子3）可促进神经和神经胶质细胞的生长和存活。 它与神经保护，和与阿尔茨海默病的风险相关的基因多态性有关。 它还与注意力缺陷/多动障碍（ADHD）和情绪障碍有关。 NT-3可增强大脑中乳腺癌细胞的转移性增殖。
Physical form
冻干品，无添加剂。
Preparation Note
在打开之前离心小瓶。在水中重悬至浓度为 0.1-1.0 mg/ml。不要涡旋。该溶液可在 2-8℃ 下储存长达 1 周。要于长期储存，建议在含有载体蛋白（例如 0.1％ BSA）的缓冲液中进一步稀释，并以 工作等分试样储存于 -20°C 至 -80°C。
Other Notes
MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Polymorphisms of the neurotrophic factor-3 (NTF-3) in Alzheimer's disease: rs6332 associated with onset time and rs6489630 T allele exhibited a protective role.
Liu M, et al.
Journal of Neurogenetics, 29, 183-187 (2015)
The neurotrophin family of neurotrophic factors: an overview.
Skaper SD
Methods in Molecular Biology, 846, 1-12 (2012)
Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis.
Louie E, et al.
Oncogene, 32, 4064-4077 (2013)
G D Yancopoulos et al.
Cold Spring Harbor symposia on quantitative biology, 55, 371-379 (1990-01-01)
Our studies of the spatiotemporal availability of neurotrophic factors, coupled with tagged ligand binding assays that identify cell bearing receptors for these factors, should lead toward defining the physiological roles of these molecules in the animal. The use of the
S O Meakin et al.
Trends in neurosciences, 15(9), 323-331 (1992-09-01)
The neurotrophins, of which nerve growth factor (NGF) is the best known example, support the survival and differentiation of chick embryo sensory neurons at extremely low concentrations, 10(-12) M or less. These same neurons display two different classes of neurotrophin
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持