IGF-Binding Protein 4 human

The gene IGFBP4 (insulin-like growth factor-binding protein 4) is mapped to human chromosome 17q21. It belongs to the IGFBP family of proteins. The protein has a IGF (insulin-like growth factor)-binding site and a thyroglobulin type-1 domain. IGFBPs are mainly required to regulate IGFs activities. IGFBP4 can be cleaved by PAPP-A (pregnancy-associated plasma protein-A) in IGF-dependent mechanism.
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

IGF-Binding Protein 4 human has been used to check the dependency of FSH (follicle-stimulating hormone) action in human Cumulus granulosa cells on IGF-2 (insulin-like growth factor 2).

IGFBP4 (insulin-like growth factor-binding protein 4) suppresses cell proliferation and DNA synthesis and induces cell death. IGFBP4 participates in adipose tissue expandability and interacts with IGF1 (insulin-like growth factor 1). Interaction with IGF1 disrupts mitogenic signaling. IGFBP4 is suggested as a serum biomarker of Lupus Nephritis and is associated with the chronicity of renal pathology in patients. IGFBP4 is also linked with cardiovascular death in type 1 diabetes patients in the absence/presence of nephropathy. It is also linked with the progression of tumors.

DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE

Lyophilized from 1x PBS, pH 7.2.

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.