生物来源
human
重组
expressed in E. coli
检测方案
≥70% (SDS-PAGE)
形式
frozen liquid
分子量
~55.3 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
浓度
100 μg/mL
颜色
clear
colorless
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... NR1I3(9970)
一般描述
The gene encoding this protein is localized on human chromosome 1q23.3.
生化/生理作用
It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling.
The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.
外形
Clear and colorless frozen liquid solution
制备说明
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation.
Osabe M
Biochemical and Biophysical Research Communications, 369(4), 1027-1033 (2008)
Molecular Genetic Studies of Gene Identification for Osteoporosis: The 2009 Update
Xiang-Hong Xu
Endocrine Reviews, 31(4), 447-505 (2010)
High resolution melting analysis of the NR1I3 genetic variants: Is there an association with neonatal hyperbilirubinemia?
Cheung TP
Gene, 573(2), 198-204 (2015)
The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor ? and Contributes to the Development of Experimental Dermal Fibrosis
Jerome Avouac
Arthritis & Rheumatology (Hoboken, N.J.) (2014)
P Wei et al.
The pharmacogenomics journal, 2(2), 117-126 (2002-06-07)
The products of the cytochrome P450 (CYP) genes play an important role in the detoxification of xenobiotics and environmental contaminants, and many foreign chemicals or xenobiotics can induce their expression. We have previously shown that the nuclear hormone receptor CAR
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