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安全信息

SRP2100

Sigma-Aldrich

MAX dimerization protein 1 (MAD) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

别名:

BHLHC58, MAD, MAD1, MGC104659

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About This Item

UNSPSC代码:
12352202
NACRES:
NA.26

生物来源

human

重组

expressed in E. coli

方案

≥80% (SDS-PAGE)

表单

frozen liquid

分子量

~26.6 kDa

包装

pkg of 10 μg

浓度

1200 μg/mL

颜色

clear colorless

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−70°C

基因信息

human ... MXD1(4084)

生化/生理作用

MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acting as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. Both Myc and Mad, as well as the more recently described Mnt and Mga proteins, form heterodimers with Max, permitting binding to specific DNA sequences. These DNA-bound heterodimers recruit coactivator or corepressor complexes that generate alterations in chromatin structure, which in turn modulate transcription. The wild-type c-Myc and c-Myc/MadBR proteins have indistinguishable biological activity and target gene recognition in vivo.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Mikhail A Nikiforov et al.
The Journal of biological chemistry, 278(13), 11094-11099 (2003-01-23)
The Myc/Max/Mad family of transcription factors plays a fundamental role in the regulation of cell proliferation, oncogenic transformation, and cell differentiation. However, it remains unclear whether different heterodimers, such as Myc/Max and Mad/Max, recognize the same or different target genes
C Grandori et al.
Annual review of cell and developmental biology, 16, 653-699 (2000-10-14)
The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or repression. A great deal of research indicates that the functions of the network play roles in cell proliferation, differentiation, and death. In

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