推荐产品
生物来源
human
重组
expressed in E. coli
检测方案
≥85% (SDS-PAGE)
形式
frozen liquid
分子量
~6.7 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
浓度
700 μg/mL
颜色
colorless to clear
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... HIF1A(3091)
一般描述
The gene encoding it is localized on human chromosome 14q23.2.
生化/生理作用
During hypoxia, the two subunits of this factor undergo post-translational modifications which in turn promote transactivation.
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1α contains two transactivation domains located between amino acids 531 and 826. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. Specific disruption of the HIF-1 pathway is important for exploring its role in tumor biology and developing more efficient weapons to treat cancer. HIF-1alpha is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF). HIF-1alpha protein expression often seen in invasive breast cancer. Recent data demonstrates that HIF-1alpha knockdown reduces tumorigenicity of MCF-7 cells and suggest a promising combination of both anti-HIF-1 strategy and traditional chemotherapy to improve cancer treatment.
外形
Clear and colorless frozen liquid solution
制备说明
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model
Human Reproduction, 30(9), 2160-2170 (2015)
Regulation of Hypoxia-Inducible Factor 1a Expression and Function by the Mammalian Target of Rapamycin
Molecular and Cellular Biology, 22(20), 7004-7014 (2002)
Multiple Gastrointestinal Stromal and Other Tumors Caused by Platelet-Derived Growth Factor Receptor a Gene Mutations: A Case Associated with a Germline V561D Defect
The Journal of Clinical Endocrinology and Metabolism, 92(9) (2007)
Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia
The Yale Journal of Biology and Medicine, 80(2), 51-60 (2007)
Knockdown of hypoxia-inducible factor-1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate.
Biochemical and Biophysical Research Communications, 342(4), 1341-1351 (2006)
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