推荐产品
生物来源
human
重组
expressed in insect cells
方案
≥80% (SDS-PAGE)
表单
frozen liquid
分子量
~28 kDa
包装
pkg of 6 μg
储存条件
avoid repeated freeze/thaw cycles
浓度
250 μg/mL
颜色
clear
colorless
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... BCL10(8915)
生化/生理作用
Bcl-10 is an intracellular signaling protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas. The human Bcl10 gene encodes a protein of 233 amino acids containing an N-terminal caspase recruitment domain (CARD) that mediates self-oligomerization and the C-terminal region of Bcl-10. Bcl 10 is expressed ubiquitously with high expression levels in lymphoid tissues and in the developing central nerve system. Mutations have been found in cases of follicular lymphoma and diffuse large B cell lymphoma. Bcl-10 is a positive regulator of antigen-receptor induced NF-kB activation and Bcl-10-initiated activation of NF-kB can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa or IkBa.
外形
Clear and colorless frozen liquid solution
制备说明
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
S M Srinivasula et al.
The Journal of biological chemistry, 274(25), 17946-17954 (1999-06-11)
Molecules that regulate NF-kappaB activation play critical roles in apoptosis and inflammation. We describe the cloning of the cellular homolog of the equine herpesvirus-2 protein E10 and show that both proteins regulate apoptosis and NF-kappaB activation. These proteins were found
Q Zhang et al.
Nature genetics, 22(1), 63-68 (1999-05-13)
Mucosa-associated lymphoid tissue (MALT) lymphomas most frequently involve the gastrointestinal tract and are the most common subset of extranodal non-Hodgkin lymphoma (NHL). Here we describe overexpression of BCL10, a novel apoptotic signalling gene that encodes an amino-terminal caspase recruitment domain
T G Willis et al.
Cell, 96(1), 35-45 (1999-02-16)
MALT B cell lymphomas with t(1;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 E10 gene: both contain an amino-terminal caspase recruitment domain (CARD) homologous to
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