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安全信息

SRP2081

Sigma-Aldrich

Retinoblastoma protein human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

别名:

OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma 1

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About This Item

UNSPSC代码:
12352202
NACRES:
NA.26

生物来源

human

重组

expressed in insect cells

方案

≥70% (SDS-PAGE)

表单

frozen liquid

分子量

~107.5 kDa

包装

pkg of 5 μg

储存条件

avoid repeated freeze/thaw cycles

浓度

400 μg/mL

颜色

clear colorless

NCBI登记号

NM_000321

UniProt登记号

P06400

运输

dry ice

储存温度

−70°C

基因信息

human ... RB1(5925)

一般描述

The gene encoding retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.

生化/生理作用

pRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of the E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-Myc, c-Fos through the binding with E2F factors and thereby regulating cell proliferation.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
072180136
67206128
051011022

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the composition of the buffer which Product SRP2081, Retinoblastoma protein human, is offered in?

    Product SRP2081, Retinoblastoma protein human, is provided in a buffer consisting of: 20 mM Tris-HCl (pH 8.0), 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA.

  6. Is there a tag still present or is it cleaved off at the time of purification for Product SRP2081, Retinoblastoma protein human?

    Product SRP2081, Retinoblastoma protein human, has a 6X His-tag attached to its N-terminus.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Thao T Le et al.
Chemical science, 11(17), 4467-4474 (2020-04-21)
Although RNA aptamers can show comparable or better specificity and affinity to antibodies and have the advantage of being able to access different live cell compartments, they are often much less stable in vivo. We report here the first aptamer
S H Friend et al.
Nature, 323(6089), 643-646 (1986-10-16)
The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that their effects can be observed when they are introduced into non-malignant cells. There is evidence for another class of oncogenes, in which tumour-predisposing mutations are recessive
W H Lee et al.
Science (New York, N.Y.), 235(4794), 1394-1399 (1987-03-13)
Recent evidence indicates the existence of a genetic locus in chromosome region 13q14 that confers susceptibility to retinoblastoma, a cancer of the eye in children. A gene encoding a messenger RNA (mRNA) of 4.6 kilobases (kb), located in the proximity
Z Onadim et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(13), 6177-6181 (1992-07-01)
The retinoblastoma-predisposition gene, RB1, segregates as an autosomal dominant trait with high (90%) penetrance. Certain families, however, show an unusual low-penetrance phenotype with many individuals being unaffected, unilaterally affected, or with evidence of spontaneously regressed tumors. We have used single-strand
Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL).
Lens D
Leukemia, 14(3), 427-430 (2000)

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