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Merck
CN

SRP0730

Sigma-Aldrich

PIP5K3 (PIKFYVE), Active

PRECISIO® Kinase, recombinant

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About This Item

UNSPSC代码:
12352202
NACRES:
NA.77

重组

expressed in baculovirus infected Sf9 cells

方案

70-95% (SDS-PAGE)

表单

frozen liquid

比活

90-115 nmol/min·mg (ADP-Glo)

分子量

~110 kDa

浓度

0.05-0.1 μg/μL

登记号

NM_015040

运输

dry ice

储存温度

−70°C

基因信息

human ... PIP5K3(200576)

应用

Useful for kinase assay.

生化/生理作用

Recombinant human PIP5K3 (1400-end) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. PIP5K3 (also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) encodes an enzyme that phosphorylates the D-5 position in PtdIns and phospha-tidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns (3,5)biphosphate. PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol but also have protein kinase activity (1). PIP5K3 regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. The inhibition of PIP5K3 renders the late endosome /lysosome compartment refractory to fusion with autop-hagosomes and multivesicular bodies (2).

储存及稳定性

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

推荐产品

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

法律信息

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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