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方案
≥95% (HPLC)
表单
aqueous solution
分子量
2728.2 kDa
包装
pkg of 5 mL
运输
dry ice
储存温度
−70°C
一般描述
BET (bromodomains and extra-terminal) domain is a highly conserved motif composed of 110 amino acids. It is composed of four anti-parallel α-helices, and contains a bromodomain in the amino-terminal region and an extraterminal (ET) protein-protein interaction domain in the carboxy-terminal region. The two conserved loops are linked with a hydrophobic cleft. This domain is present in BRD (bromodomain-containing) proteins, such as BRD2, BRD3 and BRD4, and these proteins are thus known as BET family proteins. Humans are thought to contain 56 bromodomains present in 42 proteins.
生化/生理作用
BRD (bromodomain) proteins are known as chromatin “readers”, as they recruit chromatin-regulating enzymes which are responsible for histone modification. These proteins eventually act on promoters and control gene expression.
储存分类代码
12 - Non Combustible Liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
从最新的版本中选择一种：
BET domain co-regulators in obesity, inflammation and cancer.
Belkina AC and Denis GV
Nature Reviews. Cancer, 12(7), 465-477 (2012)
Z Jasencakova et al.
The Plant cell, 12(11), 2087-2100 (2000-11-23)
Reversible acetylation of nucleosomal histones H3 and H4 generally is believed to be correlated with potential transcriptional activity of eukaryotic chromatin domains. Here, we report that the extent of H4 acetylation within euchromatin and heterochromatic domains is linked with DNA
C A Johnson et al.
Nucleic acids research, 26(4), 994-1001 (1998-03-21)
The pattern of histone H4 acetylation in different genomic regions has been investigated by immunoprecipitating oligonucleosomes from a human lymphoblastoid cell line with antibodies to H4 acetylated at lysines 5, 8, 12 or 16. DNA from antibody-bound or unbound chromatin
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