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生物来源
human
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
aqueous solution
分子量
15.5 kDa
包装
pkg of 100 μg
技术
cell based assay: suitable
溶解性
water: soluble
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... BRD4(23476)
一般描述
Research area: Cancer
BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker.Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_058243) amino-acids 49-170 with N-terminal His-tag, MW = 15.5kDa, expressed in an Escherichia coli expression system.
BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker.Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_058243) amino-acids 49-170 with N-terminal His-tag, MW = 15.5kDa, expressed in an Escherichia coli expression system.
生化/生理作用
BRD4 (bromodomain-containing protein 4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease. This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis. BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
从最新的版本中选择一种：
High level of BRD4 promotes non-small cell lung cancer progression.
Liao YF, et al.
Oncotarget, 7, 9491-9491 (2016)
Segmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase A.
Williams FP, et al.
PLoS ONE, 11, e0154607-e0154607 (2016)
BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma.
Zhang P, et al.
International Journal of Immunopathology and Pharmacology, 28, 36-36 (2015)
Philipp Voigt et al.
Genome biology, 12(11), 133-133 (2011-12-01)
The chromatin adapter BRD4 may be crucial for transmitting epigenetic information by acting as a histone acetylation-dependent gene bookmark and accelerating post-mitotic transcriptional reactivation.
R M Rodriguez et al.
Journal of molecular medicine (Berlin, Germany), 90(5), 587-595 (2011-11-29)
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human
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