生物来源
human
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥50% (SDS-PAGE)
形式
aqueous solution
分子量
115 kDa
包装
pkg of 20 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... RNF20(56254)
一般描述
Human ring finger protein 20, or RNF20 (GenBank Accession No. NM_019592) full length, amino acids 2-975 (end) with N-terminal His-Flag-tag, MW=115 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
外形
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 20% glycerol and 3 mM DTT.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Yosef Shiloh et al.
FEBS letters, 585(18), 2795-2802 (2011-08-11)
The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as the double strand break (DSB). The DDR involves extensive
Efrat Shema et al.
Molecular cell, 42(4), 477-488 (2011-05-21)
hBRE1/RNF20 is the major E3 ubiquitin ligase for histone H2B. RNF20 depletion causes a global reduction of monoubiquitylated H2B (H2Bub) levels and augments the expression of growth-promoting, pro-oncogenic genes. Those genes reside preferentially in compact chromatin and are inefficiently transcribed
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