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生物来源
human
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥87% (SDS-PAGE)
形式
aqueous solution
分子量
67 kDa
包装
pkg of 20 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... TDP2(51567)
一般描述
Human tyrosyl DNA phosphodiesterase 2, or TDP2 (GenBank Accession No. NM_016614) full length with N-terminal His-GST-tag, MW = 67 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
外形
Formulated in 40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 200 mM Imidazole, 20% Glycerol, and 3 mM DTT.
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Ka Cheong Lee et al.
International journal of molecular sciences, 19(7) (2018-07-18)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in
Christophe Marchand et al.
Molecular cancer therapeutics, 13(8), 2116-2126 (2014-07-16)
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminator-induced DNA
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