生物来源
mouse
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥65% (SDS-PAGE)
形式
aqueous solution
分子量
65 kDa
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
mouse ... PDE7B(29863)
一般描述
Mouse PDE7B (GenBank Accession No. NM_013875) amino acids 108-446 (end) with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
单位定义
1 unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5? AMP per min at 30°C.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
E Reyes-Irisarri et al.
Neuroscience, 132(4), 1173-1185 (2005-04-29)
cAMP plays an important role as second messenger molecule controlling multiple cellular processes in the brain. cAMP levels depend critically on the phosphodiesterases (PDE) activity, enzymes responsible for the clearance of intracellular cAMP. We have examined the regional distribution and
Lingzhi Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19532-19537 (2008-11-27)
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may contribute to the decreased apoptosis that occurs in chronic lymphocytic leukemia (CLL), we assessed the expression levels of PDE isoforms in
C Gardner et al.
Biochemical and biophysical research communications, 272(1), 186-192 (2000-06-29)
We have identified and characterised a novel member of the PDE7 family of cyclic nucleotide phosphodiesterases (PDE), which we have designated PDE7B. Mouse and human full-length cDNAs were isolated encoding a protein of 446 and 450 amino acids, respectively. The
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