SRP0434
PDE7A active mouse
recombinant, expressed in baculovirus infected Sf9 cells, ≥22% (SDS-PAGE)
别名:
phosphodiesterase 7A
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Assay:
≥22% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in baculovirus infected Sf9 cells
产品名称
PDE7A active mouse, recombinant, expressed in baculovirus infected Sf9 cells, ≥22% (SDS-PAGE)
biological source
mouse
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥22% (SDS-PAGE)
form
aqueous solution
mol wt
65 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... PDE7A(18583)
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
General description
Mouse PDE7A (GenBank Accession No. NM_001122759) amino acids 147-482 (end) with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.
Other Notes
1 unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5? AMP per min at 37°C.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Satoshi Yamamoto et al.
European journal of pharmacology, 541(1-2), 106-114 (2006-06-20)
YM-393059, (+/-)-N-(4,6-dimethylpyrimidin-2-yl)-4-[2-(4-methoxy-3-methylphenyl)-5-(4-methylpiperazin-1-yl)-4,5,6,7-tetrahydro-1H-indol-1-yl]benzenesulfonamide difumarate, is a novel phosphodiesterase (PDE) inhibitor that inhibited the PDE7A isoenzyme with a high potency (IC50=14 nM) and PDE4 with a moderate potency (IC50=630 nM). In a cell-based assay, YM-393059 was found to inhibit anti-CD3 antibody, Staphylococcal
Guchen Yang et al.
Journal of immunology (Baltimore, Md. : 1950), 171(12), 6414-6420 (2003-12-10)
Phosphodiesterases (PDEs) are enzymes which hydrolyze the cyclic nucleotide second messengers, cAMP and cGMP. In leukocytes, PDEs are responsible for depletion of cAMP which broadly suppresses cell functions and cellular responses to many activation stimuli. PDE7A has been proposed to
Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13.
P Han et al.
Genomics, 48(2), 275-276 (1998-04-02)
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