推荐产品
生物来源
human
重组
expressed in baculovirus infected Sf9 cells
方案
≥88% (SDS-PAGE)
表单
aqueous solution
分子量
106 kDa
包装
pkg of 5 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PDE2A(5138)
一般描述
Human PDE2A (GenBank Accession No. NM_002599) amino-acids 2-941 with N-terminal FLAG-tag, MW=106 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Joachim Seybold et al.
Blood, 105(9), 3569-3576 (2005-01-15)
The pleiotropic cytokine tumor necrosis factor-alpha (TNF-alpha) and thrombin lead to increased endothelial permeability in sepsis. Numerous studies demonstrated the significance of intracellular cyclic nucleotides for the maintenance of endothelial barrier function. Actions of cyclic adenosine monophosphate (cAMP) and cyclic
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.
Sergio E Martinez et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(20), 13260-13265 (2002-09-25)
Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory segments containing GAF domains, 3 of which are known to bind cGMP. In PDE2 binding of
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