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![Tankyrase 2 [849-1166] active human recombinant, expressed in baculovirus infected Sf9 cells, ≥30% (SDS-PAGE)](/deepweb/assets/sigmaaldrich/product/images/141/971/bb6f7e69-9c80-4ebb-8d1a-7593ae894dc6/640/bb6f7e69-9c80-4ebb-8d1a-7593ae894dc6.jpg)
生物来源
human
重组
expressed in baculovirus infected Sf9 cells
方案
≥90% (SDS-PAGE)
表单
aqueous solution
分子量
80.5 kDa
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... TNKS2(80351)
一般描述
TNKS2 (TRF1-interacting ankyrin-related ADP-ribose polymerase 2), also known as PARP5B/C, tanykyrase-2, or TNKL (GenBank Accession No. NM_025235) amino acids 667-1166 (end) with N-terminal GST-tag, MW=80.5 kDa, expressed in Sf9 cells via a Baculovirus expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
外形
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
从最新的版本中选择一种：
Brandoch D Cook et al.
Molecular and cellular biology, 22(1), 332-342 (2001-12-12)
Telomere maintenance is essential for the continuous growth of tumor cells. In most human tumors telomeres are maintained by telomerase, a specialized reverse transcriptase. Tankyrase 1, a human telomeric poly(ADP-ribose) polymerase (PARP), positively regulates telomere length through its interaction with
P G Kaminker et al.
The Journal of biological chemistry, 276(38), 35891-35899 (2001-07-17)
Tankyrase (TANK1) is a human telomere-associated poly(ADP-ribose) polymerase (PARP) that binds the telomere-binding protein TRF1 and increases telomere length when overexpressed. Here we report characterization of a second human tankyrase, tankyrase 2 (TANK2), which can also interact with TRF1 but
Natalie Sidorova et al.
Cell and tissue research, 323(1), 137-145 (2005-09-10)
Tankyrase, which functions at telomeres and other cellular compartments, is thought to be a positive regulator of telomerase; its isoenzyme tankyrase 2 has been cloned as a putative cancer antigen. This pilot immunohistochemical study was designed to examine whether tumors
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