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安全信息

SRP0423

Sigma-Aldrich

Tankyrase 2 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

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别名:
PARP5b, PARP5c, TNKS2, Tankyrase 2, poly(ADP-ribosyl)transferase 5b
UNSPSC代码:
12352200
NACRES:
NA.32

生物来源

human

重组

expressed in baculovirus infected Sf9 cells

检测方案

≥90% (SDS-PAGE)

形式

aqueous solution

分子量

80.5 kDa

包装

pkg of 10 μg

NCBI登记号

NM_025235

UniProt登记号

Q9H2K2

运输

dry ice

储存温度

−70°C

基因信息

human ... TNKS2(80351)

一般描述

TNKS2 (TRF1-interacting ankyrin-related ADP-ribose polymerase 2), also known as PARP5B/C, tanykyrase-2, or TNKL (GenBank Accession No. NM_025235) amino acids 667-1166 (end) with N-terminal GST-tag, MW=80.5 kDa, expressed in Sf9 cells via a Baculovirus expression system.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Brandoch D Cook et al.
Molecular and cellular biology, 22(1), 332-342 (2001-12-12)
Telomere maintenance is essential for the continuous growth of tumor cells. In most human tumors telomeres are maintained by telomerase, a specialized reverse transcriptase. Tankyrase 1, a human telomeric poly(ADP-ribose) polymerase (PARP), positively regulates telomere length through its interaction with
P G Kaminker et al.
The Journal of biological chemistry, 276(38), 35891-35899 (2001-07-17)
Tankyrase (TANK1) is a human telomere-associated poly(ADP-ribose) polymerase (PARP) that binds the telomere-binding protein TRF1 and increases telomere length when overexpressed. Here we report characterization of a second human tankyrase, tankyrase 2 (TANK2), which can also interact with TRF1 but
Natalie Sidorova et al.
Cell and tissue research, 323(1), 137-145 (2005-09-10)
Tankyrase, which functions at telomeres and other cellular compartments, is thought to be a positive regulator of telomerase; its isoenzyme tankyrase 2 has been cloned as a putative cancer antigen. This pilot immunohistochemical study was designed to examine whether tumors

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