生物来源
human
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥30% (SDS-PAGE)
形式
aqueous solution
分子量
62.5 kDa
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... TNKS(8658)
一般描述
TNKS1 (TRF1-interacting ankyrin-related ADP-ribose polymerase 1), also known as PARP5A, TANK1, or tanykyrase-1 (GenBank Accession No. NM_003747), amino acids 1000-1328 (end) with N-terminal GST-tag, MW=62.5 kDa, expressed in Sf9 cells via a Baculovirus expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Sandy Chang
Aging, 2(10), 639-642 (2010-11-16)
The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates
Courtney M Karner et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 239(7), 2014-2023 (2010-06-16)
Recent studies using small molecule antagonists have revealed that the poly(ADP-ribose) polymerases (PARPs) Tankyrase 1 and 2 are critical regulators of canonical Wnt signaling in some cellular contexts. However, the absence of any activity during zebrafish embryogenesis suggested that the
N McCabe et al.
Oncogene, 28(11), 1465-1470 (2009-02-03)
The BRCA1 and BRCA2 proteins are involved in the maintenance of genome stability and germ-line loss-of-function mutations in either BRCA1 or BRCA2 strongly predispose carriers to cancers of the breast and other organs. It has been demonstrated previously that inhibiting
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