推荐产品
生物来源
human
重组
expressed in baculovirus infected Sf9 cells
方案
≥35% (SDS-PAGE)
表单
aqueous solution
分子量
55 kDa
包装
pkg of 50 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... SESN2(83667)
一般描述
Sestrin 2 (SESN2), a highly conserved protein, is a member of a family of anti-aging proteins called the sestrins. Human SESN2 (hSESN2) contains three subdomains, such as SESN-A, SESN-B, and SESN-C. The SESN2 gene is mapped to human chromosome 1p35.3.
应用
Sestrin 2 human may be used to study its role on blood brain- barrier (BBB) stabilization after moderate and severe hypoxic- ischemic (HI) injuries in neonatal rats.
生化/生理作用
Sestrin 2 (SESN2) plays a vital role in modulating cellular stress response and oxidant defense. It plays a regulatory role in energy metabolism, cell fate, liver diseases, inflammation, and carcinogenesis. This novel anti-aging protein aids to maintain mitochondrial activities and enhance mitochondrial health. Since SESN2 is capable of protecting tissues from oxidative stress and mitochondrial dysfunction caused by ischemia or reperfusion (I/R), it may be a promising therapeutic target in hepatic regeneration.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
从最新的版本中选择一种：
Xudan Shi et al.
Neurobiology of disease, 95, 111-121 (2016-07-19)
Hypoxic ischemic (HI) encephalopathy remains the leading cause of perinatal brain injury resulting in long term disabilities. Stabilization of blood brain barrier (BBB) after HI is an important target, therefore, in this study we aim to determine the role of
Raúl P Oliveira et al.
Free radical biology & medicine, 163, 255-267 (2020-12-29)
Liver regeneration is a remarkably complex phenomenon conserved across all vertebrates, enabling the restoration of lost liver mass in a matter of days. Unfortunately, extensive damage to the liver may compromise this process, often leading to the death of affected
Li-Xue Wang et al.
Frontiers in immunology, 10, 2797-2797 (2019-12-24)
Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and inflammation. In recent
Broderick, G., et al.
The Pharmacogenomics Journal, 7, 407-419 (2006)
Regine Bergholdt et al.
PloS one, 4(7), e6250-e6250 (2009-07-18)
Proteins contributing to a complex disease are often members of the same functional pathways. Elucidation of such pathways may provide increased knowledge about functional mechanisms underlying disease. By combining genetic interactions in Type 1 Diabetes (T1D) with protein interaction data
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