检测方案
≥90% (HPLC)
形式
aqueous solution
包装
pkg of 80 nmol
浓度
400 μM
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CARM1(10498)
一般描述
Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.
应用
Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.
生化/生理作用
Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.
外形
Supplied in a TRIS-buffered solution.
其他说明
200 μL at 400 μM, or 80 nmol. Sold as 80 nmol
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
High-resolution genomic profiling of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) patients identified novel recurrent copy number variations involved in both pathogenesis and resistance to tyrosine kinase inhibitors
Ilaria Lacobucci
Cancer Research, 68(9) (2008)
PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines
Gundula Streubel
PLoS Genetics, 9(3), e1003343-e1003343 (2013)
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
Jacques SL
Biochemistry, 55(11), 1635-1644 (2016)
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