生物来源
human
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥90% (SDS-PAGE)
形式
aqueous solution
分子量
48 kDa (RbBP5)
51 kDa (EED)
86 kDa (EZH2)
87 kDa (SUZ12)
包装
pkg of 50 μg
运输
dry ice
储存温度
−70°C
基因信息
human ... EED(8726) , EZH2(2146) , RBBP4(5928) , SUZ12(23512)
一般描述
Complex of human EZH2 (GenBank Accession No. NM_004456), amino acids 2-end with N-terminal His-tag, MW= 86 kDa; human EED (GenBank Accession No. NM_003797) amino acids 2-end with N-terminal Flag-tag, MW= 51 kDa, human SUZ12 (GenBank Accession No. NM_015355) amino acids 2-end with N-terminal His-tag, MW = 87 kDa, and human RbAp48 (GenBank Accession No. NM_005610) amino acids 2-end with N-terminal His-tag, MW = 48 kDa, co-expressed in Baculovirus expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Rakotobe, D. et al.
Journal of Virology, 5, 32-32 (2008)
Sooryanarayana Varambally et al.
Science (New York, N.Y.), 322(5908), 1695-1699 (2008-11-15)
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain
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