生物来源
human
重组
expressed in baculovirus infected Sf9 cells
方案
≥90% (SDS-PAGE)
表单
aqueous solution
分子量
48 kDa (AEBP2)
51 kDa (EED)
53 kDa (AEBP2)
86 kDa (EZH2)
87 kDa (SUZ12)
包装
pkg of 20 μg
运输
dry ice
储存温度
−70°C
基因信息
human ... EED(8726) , EZH2(2146) , RBBP4(5928) , SUZ12(23512)
一般描述
Inactive mutant version of our regular EZH2 5-member complex, but with a Tyr-to-Cys mutation on amino acids 646 of the EZH2 protein. Complex of human EZH2 (GenBank Accession No. NM_004456), (amino acids 2-end ; Y646C*) with N-terminal His-tag, MW= 86 kDa, human EED (GenBank Accession No. NM_003797) (amino acids 2-end) with N-terminal Flag-tag, MW= 51 kDa, human SUZ12 (GenBank Accession No. NM_015355) (amino acids 2-end) with N-terminal His-tag, MW = 87 kDa, Human AEBP2 (GenBank Accession No. NM_153207) (amino acids 2-end) with N-terminal His-tag, MW= 53 kDa, and human RbAp48 (GenBank Accession No. NM_005610) (amino acids 2-end) with N-terminal His-tag, MW = 48 kDa, coexpressed in Baculovirus expression system. *This mutation is often cited as Y641C in variant 3 (GenBank Accession No. NM_001203247).
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
从最新的版本中选择一种：
Rakotobe, D. et al.
Journal of Virology, 5, 32-32 (2008)
Sooryanarayana Varambally et al.
Science (New York, N.Y.), 322(5908), 1695-1699 (2008-11-15)
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain
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