生物来源
human
重组
expressed in E. coli
检测方案
≥83% (SDS-PAGE)
形式
aqueous solution
分子量
12 kDa (DPY30)
27 kDa (MLL1)
35 kDa (WDR5)
60 kDa (RbBP5)
61 kDa (Ash2L)
包装
pkg of 50 μg
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... ASH2L(9070) , DPY30(84661) , MLL(4297) , RBBP5(5929) , WDR5(11091)
一般描述
MLL1/WARD complex of human MLL1 (GenBank Accession No. NM_005933) amino acids 3745-end with N-terminal His-tag, MW= 27 kDa, human WDR5 (GenBank Accession No. NM_017588), amino acids 22-end with N-terminal Flagtag, MW= 35 kDa, human Ash2L (GenBank Accession No. NM_001105214), amino acids 2-end with N-terminal His-tag, MW= 61 kDa, human RbBP5 (GenBank Accession No. NM_005057), amino acids 2-end with N-terminal His-tag, MW= 60 kDa, and human DPY30 (GenBank Accession No. NM_032574), amino acids 2-end with N-terminal His-tag, MW=12 kDa, individually expressed in an E. coli expression system.
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Man Mohan et al.
Nature reviews. Cancer, 10(10), 721-728 (2010-09-17)
The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation of the elongation stage of transcription could
Anamika Patel et al.
The Journal of biological chemistry, 284(36), 24242-24256 (2009-06-27)
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute
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