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生物来源
human
重组
expressed in FreeStyle™ 293-F cells
方案
≥86% (SDS-PAGE)
表单
aqueous solution
分子量
85 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
浓度
0.23 mg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... LOXL2(4017)
一般描述
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.
生化/生理作用
Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.
外形
Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.
法律信息
FreeStyle is a trademark of Invitrogen Corp.
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Olivier G de Jong et al.
Journal of cellular and molecular medicine, 20(2), 342-350 (2015-11-28)
Exosomes are important mediators of intercellular communication. Additionally, they contain a variety of components capable of interacting with the extracellular matrix (ECM), including integrins, matrix metalloproteinases and members of the immunoglobin superfamily. Despite these observations, research on exosome-ECM interactions is
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression
Alberto Martin
The Embo Journal, 34(5), 1090-1109 (2015)
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma
Keiko Mizuno
International Journal of Oncology, 48(2), 450-460 (2016)
Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma.
Nishikawa R
Febs Letters, 589(16), 2136-2145 (2015)
The function and mechanisms of action of LOXL2 in cancer (Review)
Linghong Wu and Ying Zhu
International Journal of Molecular Medicine, 1200-1204 (2015)
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