生物来源
mouse
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥50% (SDS-PAGE)
形式
aqueous solution
分子量
70 kDa
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
mouse ... MAP3K8(26410)
一般描述
Mouse Cot kinase (MAP3K8) (GenBank Accession No. NM_007746), amino acids 30-397 with N-terminal His-GST-tag, expressed in a Baculovirus infected Sf9 cell expression system.
外形
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.4 mM KCl, 5 mM glutathione, 134 mM imidazole, 3 mM DTT and 20% glycerol.
警示用语：
Danger
危险声明
危险分类
Repr. 1B
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Irene Soria-Castro et al.
The Journal of biological chemistry, 285(44), 33805-33815 (2010-08-26)
Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo. Six hours after an intraplantar injection of zymosan, Cot/tpl2(-/-)
Joseph H Jeong et al.
PloS one, 6(1), e16205-e16205 (2011-01-27)
Despite its initial positive response to hormone ablation therapy, prostate cancers invariably recur in more aggressive, treatment resistant forms. The lack of our understanding of underlying genetic alterations for the transition from androgen-dependent (AD) to ADI prostate cancer growth hampers
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