生物来源
human
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥90% (SDS-PAGE)
形式
aqueous solution
分子量
40.1 kDa
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... NEK6(10783)
一般描述
Human NEK6 (GenBank Accession No. NM_014397), amino acids 1-313 with N-terminal HIS6-tag, MW=40.1 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
单位定义
One unit is defined as the amount of enzyme that will phosphorylate 1 nmol NEK6 substrate (FLAKSFGSPNRAYKK) per minute at pH 7.4 and 30°C.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Min-Jean Yin et al.
The Journal of biological chemistry, 278(52), 52454-52460 (2003-10-18)
The Aspergillus nidulans protein NIMA (never in mitosis, gene A) is a protein kinase required for the initiation of mitosis, whereas its inactivation is necessary for mitotic exit. Here, we demonstrate that human NIMA-related kinase 6 (Nek6) is required for
Christopher Belham et al.
The Journal of biological chemistry, 278(37), 34897-34909 (2003-07-04)
The Nek family of protein kinases in humans is composed of 11 members that share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and divergent carboxyl-terminal tails of varying
Laura O'Regan et al.
The Journal of cell biology, 209(3), 349-358 (2015-05-06)
Hsp70 proteins represent a family of chaperones that regulate cellular homeostasis and are required for cancer cell survival. However, their function and regulation in mitosis remain unknown. In this paper, we show that the major inducible cytoplasmic Hsp70 isoform, Hsp72
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