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生物来源
mouse
重组
expressed in baculovirus infected Sf9 cells
形式
aqueous solution
分子量
62 kDa
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
mouse ... EGFR(13649)
一般描述
Mouse EGFR (GenBank Accession No. NM_207655/ NP_997538), amino acids 670-1210 with C-terminal Flag-tag, MW = 62 kDa, expressed in SF9 cells via a Baculovirus expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Ariel Talavera et al.
Molecular immunology, 48(12-13), 1578-1585 (2011-05-20)
The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be
Jeffrey D Kearns et al.
Molecular cancer therapeutics, 14(7), 1625-1636 (2015-04-26)
Although EGFR is a validated therapeutic target across multiple cancer indications, the often modest clinical responses to current anti-EGFR agents suggest the need for improved therapeutics. Here, we demonstrate that signal amplification driven by high-affinity EGFR ligands limits the capacity
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