推荐产品
生物来源
human
重组
expressed in E. coli
方案
≥55% (SDS-PAGE)
表单
aqueous solution
分子量
52 kDa
包装
pkg of 50 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
1 of 4
此商品 | A3611 | 735000 | A8798 |
|---|---|---|---|
| assay >95.0% (GC) | assay ≥98.5% (GC) | assay ≥98% (CP) | assay ≥99% (capillary GC) |
| biological source fungus | biological source non-animal source | biological source - | biological source Porcine liver |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form liquid | form liquid | form liquid | form waxy solid |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
一般描述
Human α tubulin acetyltransferase 1, or ATAT1, (GenBank Accession No. NM_001031722 (var1)), amino acids 2 – 224 with N-terminal GST-tag, MW=52 kDa, expressed in an E. coli expression system.
The αTAT1 (α tubulin acetyltransferase 1) protein sequence of αTAT1 is highly conserved among eukaryotes.[1][2] αTAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms.[3] It has also been identified in Tetrahymena, nematodes, zebrafish and mice.[2]
The αTAT1 (α tubulin acetyltransferase 1) protein sequence of αTAT1 is highly conserved among eukaryotes.[1][2] αTAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms.[3] It has also been identified in Tetrahymena, nematodes, zebrafish and mice.[2]
生化/生理作用
ATAT1 (α tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of α-tubulin and microtubule.[4][1] ATAT1 expression is essential for microtubule stabilization and mediates cilium formation.[4][5] Upart from acetylation, αTAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules that are not aligned with acetyltransferase activity.[1] αTAT1 regulates the Wnt1 signalling pathway via β-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression.[6]
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
A Mec17-Myosin II effector axis coordinates microtubule acetylation and actin dynamics to control primary cilium biogenesis.
Rao Y, et al.
PLoS ONE, 9(12), e114087-e114087 (2014)
Genetic disruption of tubulin acetyltransferase, ?TAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/?-catenin signaling.
Oh S, et al.
Biochemical and Biophysical Research Communications, 482(1), Aug-A14 (2017)
Microtubules acquire resistance from mechanical breakage through intralumenal acetylation.
Xu Z, et al.
Science, 356(6335), 328-332 (2017)
Structural basis of cofactor-mediated stabilization and substrate recognition of the ?-tubulin acetyltransferase ?TAT1.
Yuzawa S, et al.
The Biochemical Journal, 467(1), 103-113 (2015)
Tubulin acetylation: responsible enzymes, biological functions and human diseases.
Li L and Yang X J
Cellular and Molecular Life Sciences, 72(22), 4237-4255 (2015)
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