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安全信息

SRP0218

Sigma-Aldrich

TC-PTP Active human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

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别名:
PTPN2, T-cell protein-tyrosine phosphatase, TC-PTP
UNSPSC代码:
12352200
NACRES:
NA.32

生物来源

human

重组

expressed in E. coli

检测方案

≥90% (SDS-PAGE)

形式

aqueous solution

分子量

62.3 kDa

包装

pkg of 20 μg

储存条件

avoid repeated freeze/thaw cycles

浓度

2.9 mg/mL

NCBI登记号

BC016727

UniProt登记号

P17706

运输

dry ice

储存温度

−70°C

基因信息

human ... PTPN2(5771)

一般描述

Protein tyrosine phosphatase, Catalytic domain, (amino acids 2-315), (Gene bank accession number BC016727) with N-terminal GST tag, MW = 62.3 kDa, expressed in an E. coli expression system.

应用

Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.

单位定义

One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, and 10 mM glutathione.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Jiao Luo et al.
British journal of pharmacology, 177(19), 4464-4480 (2020-07-15)
Protein tyrosine phosphatase (PTP) 1B (PTP1B) plays a critical role in the regulation of obesity, Type 2 diabetes mellitus and other metabolic diseases. However, drug candidates exhibiting PTP1B selectivity and oral bioavailability are currently lacking. Here, the enzyme inhibitory characteristics

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