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安全信息

SRP0122

Sigma-Aldrich

LSD1 Active human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

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别名:
Amine oxidase (flavin containing) domain 2 (AOF2), BRAF35-HDAC complex protein BHC110, KIAA0601, Lysine (K)-specific demethylase 1 (LSD1), Lysine-specific histone demethylase 1A (KDM1A)
UNSPSC代码:
12352202
NACRES:
NA.32

生物来源

human

重组

expressed in E. coli

检测方案

≥70% (SDS-PAGE)

形式

aqueous solution

分子量

103 kDa

包装

pkg of 50 μg

浓度

>0.02 mg/mL

NCBI登记号

NM_015013

UniProt登记号

O60341

运输

dry ice

储存温度

−70°C

基因信息

human ... KDM1A(23028)

一般描述

Human LSD1, AOF2, amine oxidase, flavin containing, domain 2, GenBank Accession No. NM_015013, amino acids 158-end with N-terminal ST tag, MW = 103 kDa, expressed in E. coli expression system.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

单位定义

One unit is defined as the amount of enzyme required to demethylate 1 pmol of substrate/min at 37°C.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Lama AlAbdi et al.
Cell reports, 30(5), 1478-1490 (2020-02-06)
An aberrant increase in pluripotency gene (PpG) expression due to enhancer reactivation could induce stemness and enhance the tumorigenicity of cancer stem cells. Silencing of PpG enhancers (PpGe) during embryonic stem cell differentiation involves Lsd1-mediated H3K4me1 demethylation and DNA methylation. Here

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