应用
来自鲍鱼的β-葡糖苷酸已用作标准品，用于评估其在苯并二氮卓（benzodiazepine）液相色谱-质谱（LC-MS/MS）验证测试中的性能。
生化/生理作用
β-葡糖醛酸糖苷酶是存在于多种动物、植物和细菌中的酶。它催化β-葡糖苷酸偶联物和植物葡糖苷酸的水解。β-葡糖醛酸糖苷酶是糖基水解酶（GH）家族2的一员，也是一种同型四聚体糖蛋白。它促进葡糖苷酸上葡糖醛酸的去除，并有助于肝脏代谢酶排泄内源和外来物质。
单位定义
在37℃，pH 3.8（30分钟检测）条件下，一个Sigma或改良的Fishman单位可每小时从酚酞葡糖苷酸中释放1.0 μg酚酞。
外形
以含有0.85%NaCl和0.02%叠氮化钠的水溶液形式提供
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
动植物源性产品
Francesco Candeliere et al.
Frontiers in microbiology, 13, 826994-826994 (2022-03-22)
β-glucuronidases (GUS) of intestinal bacteria remove glucuronic acid from glucoronides, reversing phase II metabolism of the liver and affecting the level of active deconjugated metabolites deriving from drugs or xenobiotics. Two hundred seventy-nine non-redundant GUS sequences are known in the
Paul Awolade et al.
European journal of medicinal chemistry, 187, 111921-111921 (2019-12-14)
The emergence of disease and dearth of effective pharmacological agents on most therapeutic fronts, constitutes a major threat to global public health and man's existence. Consequently, this has created an exigency in the search for new drugs with improved clinical
Miau-Guo Kang et al.
Journal of analytical toxicology, 43(2), 96-103 (2018-10-03)
Benzodiazepines is a large drug group used extensively to treat sleep disorders and anxiety; these drugs are frequently associated with various crimes such as murder and drug-facilitated sexual assault. With growing use and misuse of these compounds, confirmatory assays are
D H Kim et al.
Biological & pharmaceutical bulletin, 22(2), 162-164 (1999-03-17)
To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected
商品
β-glucuronidase (GUS) enzymes are utilized to hydrolyze glucuronide (gluc) drug metabolites to the parent drug, facilitating analysis by LC-MS/MS.
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