产品名称
EPZ020411, ≥98% (HPLC)
assay
≥98% (HPLC)
form
(Oil (syrup))
color
colorless to faint brown
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
EPZ020411 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 10 nM; PRMT1/8 IC50 = 119/223 nM). EPZ020411 inhibits PRMT6 expression-induced H3R2 methylation in A375 cells (IC50 = 637 nM), but not PRMT1-specific methylmark (IC50 = 7.1 μM).
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