生化/生理作用
Potent and selective NF-κB-inducing kinase (NIK) inhibitor that selectively disrupts NF-κB activation in cultures and in vivo.
B022 is an ATP site-targeting, potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki = 5 nM against 5 μM ATP using mouse NIK) that inhibits NIK-induced p100-to-p52 processing (IC50 <0.5 μM; Hepa1 cells overexpressing p100 & NIK) and NF-κB2 activity (by 38% by 0.5 μM and 96% by 5 μM B022; HEK293 NIK transfectant with NF-κB reporter plasmid). B022 protects mice from death due to liver-specific NIK overexpression in mice in vivo (30 mg/kg via b.i.d.tail vein injection).
B022 is an ATP site-targeting, potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki = 5 nM against 5 μM ATP using mouse NIK) that inhibits NIK-induced p100-to-p52 processing (IC50 <0.5 μM; Hepa1 cells overexpressing p100 & NIK) and NF-κB2 activity (by 38% by 0.5 μM and 96% by 5 μM B022; HEK293 NIK transfectant with NF-κB reporter plasmid). B022 protects mice from death due to liver-specific NIK overexpression in mice in vivo (30 mg/kg via b.i.d.tail vein injection).
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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