SML3900
955, CDK9 PROTAC trifluoroacetate
≥98% (HPLC)
别名:
(E)-N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(2-(4-(2-(2,6-dimethoxy-4-(3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)phenoxy)ethyl)piperazin-1-yl)-2-oxoethyl)piperidine-4-carboxamide trifluoroacetate, PL-SNS-032 conjugate 955 trifluoroacetate
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所有图片(1)
About This Item
经验公式（希尔记法）:
C41H53N7O8S2 · xC2HF3O2
分子量:
836.03 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77
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生化/生理作用
955 CDK9 PROTAC is a cell penetrant conjugate of the CDK9 inhibitor SNS-032 with new recruiter of the E3 ligase KEAP1 piperlongumine that potently degrades CDK9 in MOLT4 cells. Similarly, to THAL-SNS-032, 955 induces CDK10 degradation. 955 exhibits potent antiproliferative activity in several prostate cancer cell lines including LNCaP, 22RV1, PC3 and DU145 cells.
Cell penetrant, potent and selective CDK9 degrader
注意
Hygroscopic
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Piperlongumine conjugates induce targeted protein degradation
Cell Chemical Biology, 30(2) (2023)
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