SML3891
Letermovir
≥98% (HPLC)
别名:
(4S)-2-{8-Fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetic acid, AIC 246, AIC-246, AIC246
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所有图片(1)
About This Item
经验公式（希尔记法）:
C29H28F4N4O4
CAS号:
分子量:
572.55
MDL编号:
UNSPSC代码:
41106609
UNSPSC代码:
12352200
NACRES:
NA.21
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
FC(F)(F)c1cc(c(cc1)OC)N2[C@H](c3c(c(ccc3)F)N=C2N4CCN(CC4)c5cc(ccc5)OC)CC(=O)O
InChI
1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1
InChI key
FWYSMLBETOMXAG-QHCPKHFHSA-N
生化/生理作用
Letermovir (AIC246) is an orally active, potent and selective human cytomegalovirus (HCMV) DNA terminase complex inhibitor that blocks HCMV replication (EC50 = 0.9-3.1 nM among 17 clinial HCMV isolates; EC50 = 1.6-3.9 nM against 6 AD169-derived drug-resistant variants) by interfering with viral DNA cleavage/packaging. Letermovir exhibits little potency toward MCMV (Smith), RCMV (Maastricht), VZV (Oka), HSV-1 (166v VP22-GFP), HSV-2 (01-6332), HHV-6 (typeA-GS) or EBV (B95-8) (MCMV EC50 = 4.5 µM, all other EC50 >10 µM).
Orally active, potent and selective human cytomegalovirus DNA terminase complex inhibitor that interfers with HCMV DNA cleavage and packaging.
警示用语：
Warning
危险声明
危险分类
Repr. 2 - STOT RE 2 Oral
靶器官
Liver,Blood,spleen
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246
Antimicrobial Agents and Chemotherapy, 54(3), 1290-1297 (2010)
In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses
Antimicrobial Agents and Chemotherapy, 56(2), 1135-1137 (2012)
The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase
Journal of virology, 85(20), 10884-10893 (2011)
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