SML3881
AK-2292
≥98% (HPLC)
别名:
((2-(((2S)-1-((2S)-2-((3-((5-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)(methyl)amino)-3-oxopropyl)(4-(thiazol-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)benzo[b]thiophen-5-yl)difluoromethyl)phosphonic acid
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About This Item
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生化/生理作用
Cell penetrant, potent and highly selective degrader of STAT5A and STAT5B isoforms.
AK-2292 is a cell penetrant, potent and highly selective PROTAC degrader of STAT5A (signal transducer and activator of transcription 5 A) and STAT5B isoforms. AK-2292 potently induces degradation of STAT5 in normal mouse tissues and human chronic myeloid leukemia (CML) xenografts in mice. It potently inhibits the growth of acute myeloid leukemia (AML) cell lines.
AK-2292 is a cell penetrant, potent and highly selective PROTAC degrader of STAT5A (signal transducer and activator of transcription 5 A) and STAT5B isoforms. AK-2292 potently induces degradation of STAT5 in normal mouse tissues and human chronic myeloid leukemia (CML) xenografts in mice. It potently inhibits the growth of acute myeloid leukemia (AML) cell lines.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo
Atsunori Kaneshige
Nature Chemical Biology, 19(6), 703-711 (2023)
Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia
Journal of medicinal chemistry, 66(4), 2717-2743 (2023)
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