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生化/生理作用
A blood-brain barrier-permeant probe for live amyloid plaques imaging by fluorescent 2-photon microscopy.
Methoxy-X04 (MeO-X04, MethoxyX04, MeX04, MX04) is a blood-brain barrier-permeant fluorescent probe derived from the Chrysamine G and Congo red scaffold that retains affinity toward amyloid beta (Aβ) fibrils (Ki = 25.3 nM/Chrysamine G and 26.8 nM/Methoxy-X04), while being much more lipophilic than Chrysamine G and Congo red. Methoxy-X04 stains Aβ plaques, tangles, and cerebrovascular amyloid in postmortem brain sections with good specificity and is commonly utilized for high-resolution fluorescent imaging of individual amyloid plaques in live animals by 2-photon microscopy (Ex. 750-800 nm; Em. 380-480, 500-540, and 560-650 nm) following i.v. or i.p. injection (5-10 mg/kg).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease
The Journal of Neuroscience, 26(2), 365-371 (2006)
Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding A? plaques by iGluSnFR two-photon imaging
Nature Communications, 7, 13441-13441 (2016)
William E Klunk et al.
Journal of neuropathology and experimental neurology, 61(9), 797-805 (2002-09-17)
The identification of amyloid deposits in living Alzheimer disease (AD) patients is important for both early diagnosis and for monitoring the efficacy of newly developed anti-amyloid therapies. Methoxy-X04 is a derivative of Congo red and Chrysamine-G that contains no acid
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