SML3833
NB-598
≥98% (HPLC)
别名:
(E)-3-[(3,3′-Bithiophen)-5-ylmethoxy]-N-(6,6-dimethyl-2-hepten-4-ynyl)- N-ethylbenzylamine, 3-([3,3′-Bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethylbenzenemethanamine, NB 598
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所有图片(2)
About This Item
经验公式（希尔记法）:
C27H31NOS2
CAS号:
分子量:
449.67
MDL编号:
UNSPSC代码:
51111800
UNSPSC代码:
12352200
NACRES:
NA.21
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (Warmed)
储存温度
-10 to -25°C
SMILES字符串
[s]1c(cc(c1)c3c[s]cc3)COc2cc(ccc2)CN(CC)C\C=C\C#CC(C)(C)C
InChI
1S/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+
InChI key
KIRGLCXNEVICOG-SOFGYWHQSA-N
生化/生理作用
NB-598 is a potent and specific inhibitor of mammalian squalene epoxidase (SQLE) that suppresses triglyceride biosynthesis through the farnesol pathway. It decreases cholesterol levels in cells. NB-598 exhibit potent cytotoxic effects in subset of f neuroendocrine tumors, such as small cell lung cancers through accumulation of toxic squalene with in sensitive cancer cells.
Potent and specific inhibitor of mammalian squalene epoxidase (SQLE) that suppresses triglyceride biosynthesis through the farnesol pathway
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
Nature Communications, 10(1), 96-96 (2019)
Hironobu Hiyoshi et al.
Journal of lipid research, 44(1), 128-135 (2003-01-09)
We recently demonstrated that squalene synthase (SQS) inhibitors reduce plasma triglyceride through an LDL receptor-independent mechanism in Watanabe heritable hyperlipidemic rabbits (Hiyoshi et al. 2001. Eur. J. Pharmacol. 431: 345-352). The present study deals with the mechanism of the inhibition
NB-598: a potent competitive inhibitor of squalene epoxidase
The Journal of biological chemistry, 265(30), 18075-18078 (1990)
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