生化/生理作用
A peroxidase-sensitive desthiobiotin-phenol (DBP) probe that offers more efficient recovery of DBP-labeled peptides from streptavidin beads and stronger mass spectrometry intensity of modified membrane proteins and achieves greater sensitivity for tyrosine residues detection. DBP shows a similar reactivity to the protein when it is converted to the phenoxyl radical state as biotin-phenol/biotin-tyramide (BP) in ascorbate peroxidase (APEX) proximity labeling. DBP exhibits reduced affinity to streptavidin and does not suffer from sulfur oxidation issue during the radical generation.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
N'-acyl-N-methylphenylenediamine as a novel proximity labeling agent for signal amplification in immunohistochemistry
Bioorganic & Medicinal Chemistry, 27(6), 1110-1118 (2019)
Enzymatic Recording of Local Hydrogen Peroxide Generation Using Genetically Encodable Enzyme
Analytical Chemistry, 14869-14877, 94(43)-94(43) (2022)
Jiyoon Beon et al.
eLife, 11 (2022-05-14)
Inositol polyphosphate multikinase (IPMK), a key enzyme in inositol polyphosphate (IP) metabolism, is a pleiotropic signaling factor involved in major biological events, including transcriptional control. In the yeast, IPMK and its IP products promote the activity of the chromatin remodeling
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