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COO原产地证书/COA分析证书

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SML3767

AA-263

Name: AA-263
Brand: SIGMA

≥98% (HPLC)

别名:

2-Hydroxybenzaldehyde 2-(4-nitrophenyl)hydrazone, NSC 101540, Salicylaldehyde 4-nitrophenylhydrazone, o-Hydroxybenzaldehyde p-nitrophenylhydrazone

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About This Item

经验公式（希尔记法）:

C₁₃H₁₁N₃O₃

CAS号:

3155-24-6

分子量:

257.24

MDL编号:

MFCD00425292

UNSPSC代码:

12352200

NACRES:

NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

, Faint orange to Red

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

[N+](=O)([O-])c1ccc(cc1)N\N=C\c2c(cccc2)O

InChI

1S/C13H11N3O3/c17-13-4-2-1-3-10(13)9-14-15-11-5-7-12(8-6-11)16(18)19/h1-9,15,17H/b14-9+

InChI key

VQIJGQPVYQKSSH-NTEUORMPSA-N

生化/生理作用

AA-263 is a cell penetrant, potent and selective ATF6 activator that corrects the trafficking, conformation, secretion, and function of AAT-Z. AA-263 increases AAT neutrophil elastase (NE) inhibitory activity, while reducing polymer accumulation for the majority of AATD (alpha-1 antitrypsin (AAT) causes AAT deficiency) variants.