推荐产品
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
O=C1N2[C@@H](C3=CC4=C(C=C3C[C@]2(C(N(C)C1)=O)[H])OCO4)C5=CNC6=CC=C(Cl)C=C56
InChI
1S/C22H18ClN3O4/c1-25-9-20(27)26-17(22(25)28)4-11-5-18-19(30-10-29-18)7-13(11)21(26)15-8-24-16-3-2-12(23)6-14(15)16/h2-3,5-8,17,21,24H,4,9-10H2,1H3/t17-,21-/m0/s1
InChI key
FSEZESVJDPKRDS-UWJYYQICSA-N
生化/生理作用
Cell-permeable, selective PIP5K1α inhibitor that blocks its downstream PI3K/AKT phosphorylation and the production of PI(4,5)P2 from its PI(4)P precursor.
ISA-2011B is a cell-permeable, selective PIP5K1α inhibitor that blocks its downstream PI3K/AKT phosphorylation and the production of PI(4,5)P2 from its PI(4)P precursor. ISA-2011B effectively inhibits propagation of both measles and nipah viruses in cell culture (40 - 50 µM) with minimal toxicity, suppresses inflammation, cancer growth and invasion in multiple models.
ISA-2011B is a cell-permeable, selective PIP5K1α inhibitor that blocks its downstream PI3K/AKT phosphorylation and the production of PI(4,5)P2 from its PI(4)P precursor. ISA-2011B effectively inhibits propagation of both measles and nipah viruses in cell culture (40 - 50 µM) with minimal toxicity, suppresses inflammation, cancer growth and invasion in multiple models.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Julius Semenas et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(35), E3689-E3698 (2014-07-30)
Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) is a lipid kinase, similar to PI3K. However, the role of PIP5K1α in oncogenic processes and the development
Tianyan Wang et al.
Frontiers in cell and developmental biology, 10, 798590-798590 (2022-04-08)
PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling pathway to promote prostate cancer (PCa) growth, survival and invasion. However, little is known of the
Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses
Cell Reports, 42(1), 111905-111905 (2023)
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