推荐产品
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
FC5(CCN(CC5)C)C[n]1cnc(c1c3c4c([nH]cc4)ncc3)c2ncc(cc2)F
InChI key
SWOIFXHMBKFCRM-UHFFFAOYSA-N
生化/生理作用
MU1742 is an orally active, potent and selective casein kinase 1 inhibitor (CK1α/δ/ε IC50 = 7/6/28 nM; p38α IC50 >3 μM) with high kinome-wide selectivity. MU1742 inhibits CLL19-induced chemotaxis (IC50 = 200 nM; MEC1 cells) and CK1δ/ε-dependent DVL3 phosphorylation (IC50 = 200 nM post 18h treatment; HL60 cells) in cultures and in lung tissue in mice in vivo (5h post 100 mg/kg p.o. using HCl salt form).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity
Angewandte Chemie (International ed. in English), 62(11) (2023)
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