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![Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) ≥95% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/235/466/8e0939d2-d5f9-46ee-ad12-f28fe40c308a/640/8e0939d2-d5f9-46ee-ad12-f28fe40c308a.png)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
生化/生理作用
Serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) interaction blocker with antidepressant efficacy in vivo.
ZZL-7 is a dipeptide that disrupts the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) by targeting the groove between the αB helix and βB folding of the nNOS PDZ domain. ZZL-7 decreases 293T cellular SERT-nNOS complex level (post 2h incubation at 1 μM) and demonstrates antidepressant efficacy in wt, but not nNos-/- mice in vivo (10, 20, and 40 mg/kg via intragastric administration or 10 mg/kg via i.p.) without undesirable side effects to the animals.
ZZL-7 is a dipeptide that disrupts the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) by targeting the groove between the αB helix and βB folding of the nNOS PDZ domain. ZZL-7 decreases 293T cellular SERT-nNOS complex level (post 2h incubation at 1 μM) and demonstrates antidepressant efficacy in wt, but not nNos-/- mice in vivo (10, 20, and 40 mg/kg via intragastric administration or 10 mg/kg via i.p.) without undesirable side effects to the animals.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN
Science, 378(6618), 390-398 (2022)
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