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别名:
4-Methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(pyridin-3-yl)thiazole-5-carboxamide, 4-Methyl-N-(2-{3-[(morpholin-4-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide, GSK 2245840B, GSK-2245840B, GSK2245840B, SRT 2104, SRT-2104
经验公式（希尔记法）:
C26H24N6O2S2
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生化/生理作用
SRT2104 is an orally active, potent and highly selective activator of the NAD+-dependent deacetylase sirtuin Sirt1 (EC1.5 = 450 nM) with in vivo efficacy in various animal models, including age-related bone/muscle loss (100 mg/kg/d via chow to mice), HD (0.5% in chow to mice), TNF-induced optic nerve degeneration (2-200 pmol via intravitreal injection to rats).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Aging Cell, 13(5), 787-796 (2014)
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells
Mechanisms of Ageing and Development, 207, 111724-111724 (2022)
Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration
Japanese Journal of Ophthalmology, 64(3), 298-303 (2020)
Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence
COPD, 17(4), 444-451 (2020)
Sirt1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating Sirt1/NF-?B pathway
Brain Research, 1753, 147236-147236 (2021)
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