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别名:
2-[3,4-bis(2-Hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one, 7,3′,4′-tris[O-(2-hydroxyethyl)]rutin, Trihydroxyethylrutin, Troxerutinum, tri(hydroxyethyl)rutoside, trioxyethylrutin, vitaminP4
经验公式（希尔记法）:
C33H42O19
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生化/生理作用
Troxerutin is a brain penetrant, vasoprotective flavonol isolated from Sophora japonica, which is present in many other plants including grains, fruits, and vegetables. Troxerutin exhibits multiple biological activities including anti-oxidative, anti-radiation, and anti-inflammatory. Recent study indicates that troxerutin improves the synaptic failure induced by Aβ peptide. It appears that Troxerutin could promote radioprotection by stimulating NEAT1 to upregulate PDPK1 expression by suppressing miR-147.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
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法规信息
新产品
F Fahmideh et al.
Frontiers in pharmacology, 13, 951833-951833 (2022-09-02)
Diabetic retinopathy (DR), one of the most common complications of diabetes mellitus, is characterized by degeneration of retinal neurons and neoangiogenesis. Until today, the pharmacological approaches for DR are limited and focused on counteracting the end-stage of this neurodegenerative disease
Yong-Jian Hu et al.
iScience, 26(2), 105932-105932 (2023-01-27)
A better understanding of the molecular mechanism involving the lncRNA-miRNA-mRNA network underlying radiation damage can be beneficial for radioprotection. This study was designed to investigate the potential role of lncRNA NEAT1, miR-147 and Phosphoinositide Dependent Protein Kinase 1 (PDPK1) interaction
Shirin Babri et al.
European journal of pharmacology, 732, 19-25 (2014-04-01)
Alzheimer׳s disease (AD) is a neurodegenerative disorder with a progressive cognitive decline and memory loss. Multiple pathogenetic factors including aggregated β-amyloid (Aβ), neurofibrillary tangles (NFTs), cholinergic dysfunction and oxidative stress are involved in AD. Aβ, a major constituent of the
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