SML3722
Dinaciclib
≥98% (HPLC)
别名:
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol, 2-[(2S)-1-[3-Ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol, MK 7965, MK-7965, MK7965, SCH 727965, SCH-727965, SCH727965
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About This Item
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
, White to light brown
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
[n+]1(cc(ccc1)CNC2=CC(=Nc4[n]2ncc4CC)N3[C@@H](CCCC3)CCO)[O-]
InChI key
PIMQWRZWLQKKBJ-SFHVURJKSA-N
生化/生理作用
Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor (CDK1/2/5/6/7/9 IC50 = 3/1/1/12/7/4 nM; Little or no inhibition of 41 other kinases at 10 μM) with potent antiproliferation activity in A2780 ovarian cancer cultures (IC50 = 4 nM by thymidine uptake assays). Dinaciclib exhibits potent anti-cancer efficacy in cultures (IC50 = 6-17 nM against 14 cancer cell lines) and in an A2780 tumor xenograft model in mice in vivo (8-48 mg/kg via daily i.p.).
Potent and selective cyclin-dependent kinase (CDK) inhibitor with potent anti-cancer efficacy in cultures and in mice in vivo.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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